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In the present study, the efficacy of 6 different species of medicinal plants belonging to 5 different families against Biomphalaria alexandrina snails and Schistosoma mansoni stages were examined. During screening test of water suspension and methanol extract, results revealed that Oreopanax reticulatum (Family: Araliaceae) had the strongest molluscicidal activity against Biomphalaria alexandrina snails followed by Azadirachta Indica A Juss (Maliaceae) and Dizygotheca kerchoveana (Family: Araliaceae). Methanol extracts revealed more molluscicidal potency as compared to water suspension. Also, the effect of methanol extracts of Oreopanax reticulatum, Azadirachta Indica A Juss (Meliaceae) and Dizygotheca kerchoveana on the survival rate and cercarial production of B. alexandrina infected with Schistosoma mansoni, as well as on free living stages of S. mansoni (miracidia, cercariae and worm) were studied. The results show that the sublethal concentrations of methanol extract of these plants caused a considerable reduction in the survival rate of the snails and in the infectivity of S.mansoni miracidia to the snail. Reduction in the number of cercariae per snail during the patent period and in the period of cercarial shedding was also, observed. The prepatent period for snails exposed to sublethal concentrations of the tested plants during their exposure to miracidia has been shortened. The mortality rate of miracidia and cercariae and adult worms were elevated gradually by increasing the exposure period to methanol extract of these plants. Key word — Plant extracts, molluscicidal, Schistosoma mansoni, Biomphalaria alexandrina ——————————  ——————————